一株人胶质瘤细胞系的连续细胞遗传学研究

Serial cytogenetic study of a human glioma cell line.

作者信息

Rey J A, Bello M J, Ramos C, Benitez J, Muelas J M

出版信息

Cancer Genet Cytogenet. 1983 Apr;8(4):287-95. doi: 10.1016/0165-4608(83)90071-7.

Abstract

Chromosome studies were performed on a human glioma cell line. Nineteen passages were studied, and a heterogeneous chromosome complement with variable modal numbers was found. The main range varied from tetraploidy to triploidy. The presence of identical markers (9p-, 11p+, an increase in the copies of chromosome No. 7) in different passages suggests a clonal evolution.

摘要

对一株人类胶质瘤细胞系进行了染色体研究。研究了19个传代培养物，发现其染色体组成具有异质性，众数可变。主要范围从四倍体到三倍体。不同传代培养物中存在相同的标记（9号染色体短臂缺失、11号染色体短臂增加、7号染色体拷贝数增加），提示存在克隆进化。