Jensen B, Williams R D, Ohnuma T, Roboz J
Cancer Treat Rep. 1983 Mar;67(3):283-4.
Methyl-GAG at low doses was administered to an anephric male patient with metastatic hypernephroma, who required hemodialysis. No toxicity was observed. Measurement of serum levels of methyl-GAG showed that the drug is dialyzable. Thus, when methyl-GAG is considered for patients who are anephric and are being dialyzed, full doses are allowable. In addition, dialysis should be effective in rapidly eliminating the drug in patients who develop toxic effects.
对一名患有转移性肾细胞癌且需要血液透析的无肾男性患者给予低剂量的甲基葡糖胺聚糖（Methyl-GAG），未观察到毒性。甲基葡糖胺聚糖血清水平的测定表明该药物是可透析的。因此，对于无肾且正在接受透析的患者考虑使用甲基葡糖胺聚糖时，可以给予全剂量。此外，透析对于迅速清除出现毒性反应患者体内的药物应该是有效的。
