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棉尘细菌刺激人多形核白细胞导致血小板5-羟色胺释放。

Platelet serotonin release by human polymorphonuclear leucocytes stimulated by cotton dust bacteria.

作者信息

Holt P G, Holt B J, Beijer L, Rylander R

出版信息

Clin Exp Immunol. 1983 Jan;51(1):185-90.

Abstract

The release of serotonin from platelets was examined using polymorphonuclear leucocytes (PMN) from normal volunteers. The stimulating agents emplyed were zymosan and heat-killed bacteria from , which is commonly found in cotton dust. Optimal conditions for release were established. Both zymosan and yielded a release of serotonin of an equal magnitude. The data are discussed in relation to the pathogenesis of respiratory disease associated with occupational exposure to cotton dust.

摘要

利用正常志愿者的多形核白细胞(PMN)检测血小板中血清素的释放情况。所使用的刺激剂是酵母聚糖和来自棉花粉尘中常见的[某种细菌]的热灭活细菌。确定了释放的最佳条件。酵母聚糖和[该细菌]均产生了等量的血清素释放。结合职业性接触棉花粉尘相关呼吸道疾病的发病机制对这些数据进行了讨论。

本文引用的文献

1
2
Prevalence of byssinosis in Swedish cotton mills.
Br J Ind Med. 1981 May;38(2):138-43. doi: 10.1136/oem.38.2.138.
3
Chemical structure and inhalation toxicity of lipopolysaccharides from bacteria on cotton.
Infect Immun. 1980 Sep;29(3):859-62. doi: 10.1128/iai.29.3.859-862.1980.

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