Henson P M
J Exp Med. 1970 Feb;131(2):287-306. doi: 10.1084/jem.131.2.287.
The immunological release of vasoactive amines from rabbit platelets by a mechanism requiring blood leukocytes has been described. The reaction involved leukocytes from an immunized rabbit, antigen, and platelets and did not require the complement system. The leukocytes appeared to be mononuclear, had the ability to adhere to glass, and were found in greater numbers in the blood than in spleen, lymph nodes, thoracic duct lymph, bone marrow, and peritoneal cavity washings. Part or all of the effect on the platelets appeared to result from active release of a soluble factor from the leukocytes, which induced vasoactive amine release from the platelets. The platelets were not lysed during this reaction and the release of vasoactive amines required the active participation of metabolic pathways in the platelet.
已描述了通过一种需要血液白细胞的机制，从兔血小板中免疫释放血管活性胺的过程。该反应涉及来自免疫兔的白细胞、抗原和血小板，且不需要补体系统。这些白细胞似乎是单核细胞，具有黏附于玻璃的能力，并且在血液中发现的数量比在脾脏、淋巴结、胸导管淋巴液、骨髓和腹腔冲洗液中的更多。对血小板的部分或全部作用似乎是由于白细胞主动释放一种可溶性因子所致，该因子诱导血小板释放血管活性胺。在此反应过程中血小板未被裂解，血管活性胺的释放需要血小板中代谢途径的积极参与。
