Windorfer A, Stünkel S, Weinmann H M
Monatsschr Kinderheilkd (1902). 1978 Aug;126(8):507-11.
Serum levels of primidone and phenobarbital were measured and showed a relatively constant ratio in patients under primidone monotherapy. In outpatients, however, this ratio was lower and the range of its values wider than in hospitalized children, and the difference was significant (1:2.05 or 1:2.95). The reason for this turned out to be irregular intake of the drug by the outpatients. The ratio of primidone to phenobarbital serum levels offers itself as a control of regularity of intake of primidone.
测定了使用扑米酮单一疗法患者的血清扑米酮和苯巴比妥水平，结果显示二者比例相对恒定。然而，门诊患者的该比例较低，其值范围比住院儿童更宽，且差异显著（1:2.05或1:2.95）。结果发现，原因是门诊患者用药不规律。扑米酮与苯巴比妥血清水平的比例可用于控制扑米酮摄入的规律性。
