Smith J H, McCormack K M, Braselton W E, Hook J B
Environ Res. 1983 Feb;30(1):63-71. doi: 10.1016/0013-9351(83)90167-6.
In utero exposure of rats to methylmercury has been reported to produce degenerative and hyperplastic changes in renal proximal and distal tubules, although no assessment of postnatal renal functional capacity was made. CH3HgCl was administered ip to Sprague-Dawley rats on Day 8 of gestation at 4 or 6 mg Hg/kg or on Days 8, 10, and 12 at 4 mg Hg/kg (3 x 4 mg Hg/kg). These doses produced no overt toxicological effects nor had any effect on litter size, body weight, or kidney weight to body weight ratios. The concentration of mercury in kidneys, liver, and brain at 1 and 7 days postpartum was dose-related but was not detectable at 42 days. In vitro renal function was assessed in renal cortical slices from rats at 1, 7, and 42 days postpartum by determining the ability to accumulate organic ions and to generate glucose. Additionally, parameters of in vivo renal function were determined in normopenic, hydropenic (5 pressor units/kg ADH, sc, 18 hr water deprived), and in volume-loaded male rats at 42 days postpartum. At 42 days postpartum in the 3 x 4 mg Hg/kg treatment group, p-aminohippurate accumulation was depressed slightly as was the ability to eliminate Na+ and water in volume-loaded rats. These data suggest that postnatal renal physiological sequelae to prenatal administration of methylmercury may be less than predicted from histological studies.
据报道，大鼠在子宫内接触甲基汞会导致肾近端和远端小管出现退行性和增生性变化，不过未对产后肾功能进行评估。在妊娠第8天，以4或6毫克汞/千克的剂量腹腔注射氯化甲基汞给斯普拉格-道利大鼠，或者在第8、10和12天以4毫克汞/千克的剂量（3×4毫克汞/千克）注射。这些剂量未产生明显的毒理学效应，对窝仔数、体重或肾重与体重之比也没有影响。产后1天和7天时，肾脏、肝脏和大脑中的汞浓度与剂量相关，但在42天时无法检测到。通过测定积累有机离子和生成葡萄糖的能力，对产后1天、7天和42天的大鼠肾皮质切片进行体外肾功能评估。此外，在产后42天，对正常排尿、禁水（皮下注射5个升压单位/千克抗利尿激素，禁水18小时）和容量负荷雄性大鼠测定体内肾功能参数。在产后42天的3×4毫克汞/千克治疗组中，对氨基马尿酸盐的积累略有下降，容量负荷大鼠消除钠和水的能力也有所下降。这些数据表明，产前给予甲基汞对产后肾脏生理后遗症的影响可能小于组织学研究所预测的。
