Gisslèn H, Nordin P
J Int Med Res. 1983;11(1):46-50. doi: 10.1177/030006058301100110.
In Dithranol cream the oily phase is emulsified with an aqueous phase to make the preparation more convenient to apply. The cream also contains ascorbic acid as an antioxidant, which protects dithranol against atmospheric oxidation, thus increasing its stability. A stylus containing dithranol, ol. cacao, paraffin and vaselinum has been used as a comparative drug. The stylus is routinely used in this clinic. Sixty patients with stable psoriasis were pre-assigned into two treatment groups, receiving at random Dithranol cream 0.1%, 0.25% and Dithranol stylus 0.1%, 0.2%, respectively. Both groups started their treatment with the 0.1% preparation once a day for 2 weeks followed by the 0.2% or 0.25% preparations once a day for another 2 weeks. The following laboratory tests: Hb, WBC, Diff, S-ALAT, S-ASAT and S-creatinine were recorded before and after treatment. Staining of clothes was none to slight in 70% (21/30) of the patients using Dithranol stylus 0.2%, and 80% (24/30) in the patients using Dithranol cream 0.25%. The sensation of burning was none to slight in 83% (25/30) of the patients and skin discolouration was none to slight in approximately 80% (24/30) of the patients using the Dithranol stylus 0.2% and Dithranol cream 0.25% preparations. Both groups showed significant improvement in all effect-variables after 2 and 4 weeks' treatment compared to initial. The results are over all better after 4 weeks' treatment than after 2. No abnormal values due to dithranol treatment could be found in the laboratory tests.
在地蒽酚乳膏中，油相被水相乳化，以使制剂更便于涂抹。该乳膏还含有抗坏血酸作为抗氧化剂，可保护地蒽酚免受大气氧化，从而提高其稳定性。一种含有地蒽酚、可可油、石蜡和凡士林的笔剂已被用作对照药物。该笔剂在本诊所常规使用。60例稳定期银屑病患者预先被分为两个治疗组，分别随机接受0.1%、0.25%的地蒽酚乳膏和0.1%、0.2%的地蒽酚笔剂治疗。两组均以0.1%的制剂开始治疗，每天一次，持续2周，随后以0.2%或0.25%的制剂每天一次，再持续2周。记录治疗前后的以下实验室检查结果：血红蛋白（Hb）、白细胞（WBC）、分类、血清谷丙转氨酶（S-ALAT）、血清谷草转氨酶（S-ASAT）和血清肌酐。使用0.2%地蒽酚笔剂的患者中，70%（21/30）衣物染色为无至轻度，使用0.25%地蒽酚乳膏的患者中，80%（24/30）衣物染色为无至轻度。使用0.2%地蒽酚笔剂和0.25%地蒽酚乳膏制剂的患者中，83%（25/30）有无至轻度的灼烧感，约80%（24/30）的患者有无至轻度的皮肤变色。与初始情况相比，两组在治疗2周和4周后所有疗效变量均有显著改善。4周治疗后的结果总体上比2周后更好。实验室检查未发现因使用地蒽酚治疗导致的异常值。
