Lind T, Cederberg C, Ekenved G, Haglund U, Olbe L
Gut. 1983 Apr;24(4):270-6. doi: 10.1136/gut.24.4.270.
The effect of oral omeprazole on pentagastrin stimulated gastric acid secretion was studied in 11 healthy subjects. Doses of 20-80 mg produced dose dependent inhibition of acid secretion, with total suppression at the highest dose. Omeprazole was absorbed and eliminated from plasma rapidly and the inhibitory effect was related to the area under the plasma concentration time curve. The duration of action was long and single doses of 20 and 40 mg reduced acid secretion significantly for one and three days, respectively. Omeprazole in a dose of 15 mg given once daily for five days, suppressed acid secretion continuously, the inhibitory effect stabilising after three days at a predose inhibition of about 30% and a postdose inhibition of about 80%.
在11名健康受试者中研究了口服奥美拉唑对五肽胃泌素刺激胃酸分泌的影响。20 - 80毫克剂量产生了剂量依赖性的胃酸分泌抑制作用，最高剂量时完全抑制。奥美拉唑从血浆中快速吸收和消除，其抑制作用与血浆浓度-时间曲线下面积有关。作用持续时间长，20毫克和40毫克单剂量分别使胃酸分泌显著减少1天和3天。每天一次给予15毫克奥美拉唑，连续5天，持续抑制胃酸分泌，3天后抑制作用稳定，给药前抑制约30%，给药后抑制约80%。
