奥美拉唑（一种胃质子泵抑制剂）对人五肽胃泌素刺激的胃酸分泌的影响。
Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man.
作者信息
Lind T, Cederberg C, Ekenved G, Haglund U, Olbe L
出版信息
Gut. 1983 Apr;24(4):270-6. doi: 10.1136/gut.24.4.270.
Abstract
The effect of oral omeprazole on pentagastrin stimulated gastric acid secretion was studied in 11 healthy subjects. Doses of 20-80 mg produced dose dependent inhibition of acid secretion, with total suppression at the highest dose. Omeprazole was absorbed and eliminated from plasma rapidly and the inhibitory effect was related to the area under the plasma concentration time curve. The duration of action was long and single doses of 20 and 40 mg reduced acid secretion significantly for one and three days, respectively. Omeprazole in a dose of 15 mg given once daily for five days, suppressed acid secretion continuously, the inhibitory effect stabilising after three days at a predose inhibition of about 30% and a postdose inhibition of about 80%.
摘要
在11名健康受试者中研究了口服奥美拉唑对五肽胃泌素刺激胃酸分泌的影响。20 - 80毫克剂量产生了剂量依赖性的胃酸分泌抑制作用，最高剂量时完全抑制。奥美拉唑从血浆中快速吸收和消除，其抑制作用与血浆浓度-时间曲线下面积有关。作用持续时间长，20毫克和40毫克单剂量分别使胃酸分泌显著减少1天和3天。每天一次给予15毫克奥美拉唑，连续5天，持续抑制胃酸分泌，3天后抑制作用稳定，给药前抑制约30%，给药后抑制约80%。
相似文献
1
Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man.奥美拉唑（一种胃质子泵抑制剂）对人五肽胃泌素刺激的胃酸分泌的影响。
Gut. 1983 Apr;24(4):270-6. doi: 10.1136/gut.24.4.270.
2
Effects of single and repeated doses of omeprazole on gastric acid and pepsin secretion in man.单次及重复剂量奥美拉唑对人体胃酸和胃蛋白酶分泌的影响。
Gut. 1984 Jul;25(7):707-10. doi: 10.1136/gut.25.7.707.
3
Acid inhibitory characteristics of omeprazole in man.奥美拉唑对人体的抑酸特性。
Scand J Gastroenterol Suppl. 1985;108:105-12. doi: 10.3109/00365528509095823.
4
Omeprazole inhibits nocturnal and pentagastrin-stimulated gastric secretion in man.奥美拉唑可抑制人体夜间及五肽胃泌素刺激的胃酸分泌。
Dig Dis Sci. 1984 Sep;29(9):797-801. doi: 10.1007/BF01318421.
5
[Suppression of acid secretion and plasma level of a once-daily dose of omeprazole].
Arzneimittelforschung. 1983;33(12):1685-6.
6
Effect of omeprazole on gastric acid secretion in man.奥美拉唑对人体胃酸分泌的影响。
Scand J Gastroenterol Suppl. 1986;118:105-7. doi: 10.3109/00365528609090908.
7
Omeprazole, a long-lasting inhibitor of gastric secretion.
J Surg Res. 1984 May;36(5):503-7. doi: 10.1016/0022-4804(84)90133-1.
8
Inhibition of pentagastrin-stimulated gastric acid secretion by pantoprazole and omeprazole in healthy adults.泮托拉唑和奥美拉唑对健康成年人五肽胃泌素刺激胃酸分泌的抑制作用。
Dig Dis Sci. 2006 Jan;51(1):123-31. doi: 10.1007/s10620-006-3096-0.
9
Effect of single and repeated intravenous doses of omeprazole on pentagastrin stimulated gastric acid secretion and pharmacokinetics in man.单次及重复静脉注射奥美拉唑对人五肽胃泌素刺激胃酸分泌及药代动力学的影响。
Gut. 1988 Jan;29(1):75-80. doi: 10.1136/gut.29.1.75.
10
Effects of IY-81149, a newly developed proton pump inhibitor, on gastric acid secretion in vitro and in vivo.新型质子泵抑制剂IY-81149对体外和体内胃酸分泌的影响。
Arzneimittelforschung. 2001;51(3):204-13. doi: 10.1055/s-0031-1300026.
引用本文的文献
1
Leveraging Omeprazole PBPK/PD Modeling to Inform Drug-Drug Interactions and Specific Recommendations for Pediatric Labeling.利用奥美拉唑药代动力学/药效学（PBPK/PD）模型来指导药物相互作用及儿科标签的具体建议。
Pharmaceutics. 2025 Mar 14;17(3):373. doi: 10.3390/pharmaceutics17030373.
2
Experimental solubility of omeprazole in pure and ethanol-modified subcritical water.奥美拉唑在纯亚临界水和乙醇改性亚临界水中的实验溶解度。
Sci Rep. 2024 Nov 23;14(1):29073. doi: 10.1038/s41598-024-75829-9.
3
Pharmacokinetics and Pharmacodynamics of Esomezol DR, a New Dual Delayed-Release Formulation of Esomeprazole 20 Mg or 40 Mg, in Healthy Subjects.艾司奥美拉唑 DR 的药代动力学和药效学：一种新的艾司奥美拉唑 20mg 或 40mg 双重延迟释放制剂在健康受试者中的研究。
Drug Des Devel Ther. 2023 Apr 12;17:1115-1124. doi: 10.2147/DDDT.S392533. eCollection 2023.
4
Prediction of gastric pH-mediated drug exposure using physiologically-based pharmacokinetic modeling: A case study of itraconazole.基于生理的药代动力学模型预测胃 pH 值介导的药物暴露：以伊曲康唑为例的案例研究。
CPT Pharmacometrics Syst Pharmacol. 2023 Jun;12(6):865-877. doi: 10.1002/psp4.12959. Epub 2023 Mar 26.
5
Quality by Design Applied Development of Immediate-Release Rabeprazole Sodium Dry-Coated Tablet.基于质量源于设计理念的速释型雷贝拉唑钠干包衣片的应用开发
Pharmaceutics. 2021 Feb 14;13(2):259. doi: 10.3390/pharmaceutics13020259.
6
Effect of food on the pharmacokinetics of omeprazole, pantoprazole and rabeprazole.食物对奥美拉唑、泮托拉唑和雷贝拉唑药代动力学的影响。
BMC Pharmacol Toxicol. 2020 Jul 25;21(1):54. doi: 10.1186/s40360-020-00433-2.
7
Analysis of the symptom response to esomeprazole 20 mg over days 1-4 of a 14-day course of treatment for frequent heartburn: results of two randomised controlled trials.在为期14天的频繁烧心治疗疗程中，分析第1 - 4天服用20毫克埃索美拉唑后的症状反应：两项随机对照试验的结果。
BMJ Open Gastroenterol. 2019 Jun 21;6(1):e000278. doi: 10.1136/bmjgast-2019-000278. eCollection 2019.
8
Effects of Cyclodextrins (β and γ) and l-Arginine on Stability and Functional Properties of Mucoadhesive Buccal Films Loaded with Omeprazole for Pediatric Patients.环糊精（β-环糊精和γ-环糊精）和L-精氨酸对载有奥美拉唑的儿科用黏附性口腔膜稳定性和功能特性的影响
Polymers (Basel). 2018 Feb 7;10(2):157. doi: 10.3390/polym10020157.
9
Comparison of double-flap and OrVil techniques of laparoscopy-assisted proximal gastrectomy in preventing gastroesophageal reflux: a retrospective cohort study.腹腔镜辅助近端胃切除术双瓣法与OrVil技术预防胃食管反流的比较：一项回顾性队列研究
Langenbecks Arch Surg. 2019 Feb;404(1):81-91. doi: 10.1007/s00423-018-1743-5. Epub 2019 Jan 5.
10
Reply.回复。
Clin Gastroenterol Hepatol. 2017 Sep;15(9):1480-1481. doi: 10.1016/j.cgh.2017.04.018. Epub 2017 Apr 15.
本文引用的文献
1
Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase.取代苯并咪唑通过阻断（H⁺+K⁺）ATP酶来抑制胃酸分泌。
Nature. 1981 Mar 12;290(5802):159-61. doi: 10.1038/290159a0.
2
Furan H2-antagonist ranitidine inhibits pentagastrin-stimulated gastric secretion stronger than cimetidine.呋喃类H2拮抗剂雷尼替丁比西咪替丁更能强烈抑制五肽胃泌素刺激的胃酸分泌。
Gastroenterology. 1980 Dec;79(6):1267-71.
3
Properties of a new class of gastric acid inhibitors.一类新型胃酸抑制剂的特性
Scand J Gastroenterol Suppl. 1979;55:131-5.
4
Characterization of gastric mucosal membranes. X. Immunological studies of gastric (H+ + K+)-ATPase.胃黏膜膜的特性。X. 胃（H⁺ + K⁺）-ATP酶的免疫学研究。
J Cell Biol. 1979 Nov;83(2 Pt 1):271-83. doi: 10.1083/jcb.83.2.271.
5
A nonelectrogenic H+ pump in plasma membranes of hog stomach.猪胃质膜中的一种非电生性氢离子泵。
J Biol Chem. 1976 Dec 10;251(23):7690-8.
Zotero 插件