Schulz V
Fortschr Med. 1983 Jan 27;101(4):126-9.
Sodium nitroprusside (SNP) as a monoinfusion was administered to 50 patients for periods of a few hours. A further group of 20 patients received SNP for periods of several days as a combination solution, of SNP mixed with sodium thiosulphate. Infusion of SNP on its own at levels exceeding 2 micrograms/kg/min led to cyanide levels in the blood rising proportional to dosage. Infusion of SNP mixed with thiosulphate showed no such accumulation. This procedure is free of danger and should become the technique of choice when therapeutically administering SNP to lower blood pressure.
50名患者接受了硝普钠（SNP）单次输注，持续数小时。另有20名患者接受了SNP与硫代硫酸钠混合的复合溶液输注，持续数天。单独输注SNP时，剂量超过2微克/千克/分钟会导致血液中氰化物水平随剂量成比例升高。输注SNP与硫代硫酸钠的混合溶液则未出现这种蓄积现象。该方法无危险，在治疗性使用SNP降低血压时应成为首选技术。
