McCullough J
Hum Pathol. 1983 Mar;14(3):228-34. doi: 10.1016/s0046-8177(83)80022-7.
Granulocyte alloantibodies and autoantibodies have a key role in the pathophysiology of several clinical problems. These include febrile transfusion reactions, severe pulmonary reactions to transfusion, isoimmune neonatal neutropenia, failure of effective granulocyte transfusion, autoimmune neutropenia, drug-induced neutropenia, and neutropenias secondary to many other diseases. Although many techniques are available for detecting granulocyte antibodies, the optimal in-vitro tests for predicting the antibodies' clinical effects are not established. Use of indium-111-labeled granulocytes may provide valuable information regarding the in-vivo effects of different granulocyte antibodies. Granulocyte transfusions continue to be used for a limited number of severely infected neutropenic patients who do not respond to antibiotic therapy.
粒细胞同种抗体和自身抗体在一些临床问题的病理生理学中起关键作用。这些问题包括发热性输血反应、输血后严重肺部反应、同种免疫性新生儿中性粒细胞减少症、有效的粒细胞输注失败、自身免疫性中性粒细胞减少症、药物性中性粒细胞减少症以及继发于许多其他疾病的中性粒细胞减少症。尽管有许多技术可用于检测粒细胞抗体，但尚未确定预测抗体临床效应的最佳体外试验。使用铟-111标记的粒细胞可能会提供有关不同粒细胞抗体体内效应的有价值信息。粒细胞输注仍用于少数对抗生素治疗无反应的严重感染中性粒细胞减少患者。
