Baer W, Chmiel J, Gnojkowski J, Klimek D
Int J Clin Pharmacol Ther Toxicol. 1983 Jan;21(1):41-6.
The effect of two sesquiterpene lactones of the germacranolide group, eupatoriopicrin and hydroxyisonobilin, on the glycolytic metabolism of human lymphocytes stimulated by phytohemagglutinin was tested. Glucose and lactic acid levels as well as the activities of phosphofructokinase, glyceraldehyde 3-phosphate dehydrogenase, pyruvate kinase, and lactate dehydrogenase were measured. Both lactones caused a decrease in glucose consumption and lactic acid formation as well as the inhibition of the tested enzymes. A stronger inhibitory effect was observed in the case of hydroxyisonobilin, particularly with regard to phosphofructokinase and glyceraldehyde 3-phosphate dehydrogenase.
测试了吉马烷型倍半萜内酯类的两种成分，泽兰苦内酯和羟基异土木香苦素，对植物血凝素刺激的人淋巴细胞糖酵解代谢的影响。测定了葡萄糖和乳酸水平以及磷酸果糖激酶、3-磷酸甘油醛脱氢酶、丙酮酸激酶和乳酸脱氢酶的活性。两种内酯均导致葡萄糖消耗和乳酸生成减少以及受试酶受到抑制。羟基异土木香苦素表现出更强的抑制作用，尤其是对磷酸果糖激酶和3-磷酸甘油醛脱氢酶。
