Pask-Hughes R A, Hartley R E, Gaines Das R E
J Biol Stand. 1983 Jan;11(1):13-7. doi: 10.1016/s0092-1157(83)80041-9.
This paper reports the comparison of recently-developed chromatographic assays (using high performance liquid chromatography) with the present British Pharmacopoeial methods for the combined formulation of ergometrine and oxytocin. The estimates using high performance liquid chromatography were in good agreement with both the Pharmacopoeial determinations and nominal contents. The variability of estimates for ergometrine was similar for both procedures, whereas the variability of estimates of oxytocin content by chromatographic assay was significantly less than the variability of estimates by the Pharmacopoeial bioassay.
本文报道了最近开发的色谱分析方法（使用高效液相色谱法）与英国药典现行方法对麦角新碱和缩宫素联合制剂的比较。使用高效液相色谱法的测定结果与药典测定结果和标称含量均高度一致。两种方法对麦角新碱的估计变异性相似，而色谱分析法对缩宫素含量估计的变异性明显小于药典生物测定法的估计变异性。
