Hamby R I, Noble W J, Murphy D H, Hoffman I
J Am Coll Cardiol. 1983 Apr;1(4):1011-7. doi: 10.1016/s0735-1097(83)80102-8.
The atrial contribution to ventricular stroke volume was evaluated in 50 patients with coronary artery disease and found to be related to left ventricular function. All patients underwent complete hemodynamic and angiographic studies. Angiographic volume studies were utilized to determine atrial contribution to the stroke volume, end-systolic volume and ejection fraction. In 11 patients without heart disease, atrial contribution to stroke volume was (mean value +/- standard deviation) 9.3 +/- 6 ml/m2 compared with 13.5 +/- 6 ml/m2 in the patients with coronary disease (probability [p] less than 0.05). The percent of atrial contribution to stroke volume was 20 +/- 7 and 33 +/- 11%, respectively, in normal subjects and patients with coronary disease (p less than 0.05). The combination of congestive heart failure and cardiomegaly was the only clinical aspect associated with a significantly higher (p less than 0.05) atrial contribution to stroke volume than that in the remaining patients with coronary disease (46 versus 31%). Relating the atrial contribution to stroke volume to the left ventricular end-diastolic pressure, stroke volume, end-systolic volume and ejection fraction revealed correlation coefficients of 0.30, -0.44, 0.56 and -0.64, respectively. No patient with a normal ejection fraction (greater than 0.50) had an atrial contribution greater than 40% of stroke volume. The ratio of peak left ventricular systolic pressure/end-systolic volume (mm Hg/ml) was 2.7 +/- 1.5 in patients (n = 14) with an atrial contribution greater than 40% of stroke volume compared with 5.3 +/- 3.4 in patients having an atrial contribution of 40% or less (p less than 0.01). These findings indicate that atrial contribution to stroke volume is inversely related to left ventricular function.
对50例冠心病患者的心房对心室每搏输出量的贡献进行了评估，发现其与左心室功能有关。所有患者均接受了完整的血流动力学和血管造影研究。利用血管造影容积研究来确定心房对每搏输出量、收缩末期容积和射血分数的贡献。在11例无心脏病患者中，心房对每搏输出量的贡献为（平均值±标准差）9.3±6 ml/m²，而冠心病患者为13.5±6 ml/m²（概率[p]小于0.05）。正常受试者和冠心病患者心房对每搏输出量的贡献百分比分别为20±7%和33±11%（p小于0.05）。充血性心力衰竭和心脏扩大的组合是唯一与心房对每搏输出量的贡献显著高于其余冠心病患者（46%对31%）相关的临床情况（p小于0.05）。将心房对每搏输出量的贡献与左心室舒张末期压力、每搏输出量、收缩末期容积和射血分数相关联，发现相关系数分别为0.30、-0.44、0.56和-0.64。射血分数正常（大于0.50）的患者中，没有心房对每搏输出量的贡献超过40%。心房对每搏输出量的贡献大于40%的患者（n = 14）的左心室收缩压峰值/收缩末期容积（mmHg/ml）比值为2.7±1.5，而心房贡献为40%或更低的患者为5.3±3.4（p小于0.01）。这些发现表明，心房对每搏输出量的贡献与左心室功能呈负相关。
