Lundell B P, Lagercrantz H
J Dev Physiol. 1983 Feb;5(1):23-9.
Left ventricular systolic time intervals and plasma noradrenaline concentrations were determined in twelve newborn infants during acute moderate hypovolaemia. Rapid withdrawal of 8.5 ml of blood per kg body weight shortened the left ventricular ejection time from 204 to 176 msec (P less than 0.001) and increased the plasma noradrenaline concentration from 3.4 to 4.0 nmol/l (P less than 0.05). Systemic blood pressure was unchanged. It is concluded that even a moderate reduction in blood volume is associated with marked changes in left ventricular dynamics. The shortening of left ventricular ejection time during hypovolaemia probably reflects left ventricular adaptation to decreased volumes and response to increased noradrenaline release.
在12名新生儿急性中度血容量减少期间，测定了左心室收缩时间间期和血浆去甲肾上腺素浓度。每千克体重快速抽取8.5毫升血液，使左心室射血时间从204毫秒缩短至176毫秒（P<0.001），并使血浆去甲肾上腺素浓度从3.4纳摩尔/升增加至4.0纳摩尔/升（P<0.05）。全身血压未发生变化。得出的结论是，即使是血容量的适度减少也与左心室动力学的显著变化相关。低血容量期间左心室射血时间的缩短可能反映了左心室对容量减少的适应以及对去甲肾上腺素释放增加的反应。
