光化性角化病患者细胞中的DNA修复
DNA repair in cells from patients with actinic keratosis.
作者信息
Abo-Darub J M, MacKie R, Pitts J D
出版信息
J Invest Dermatol. 1983 Apr;80(4):241-4. doi: 10.1111/1523-1747.ep12534540.
PMID:6833781
Abstract
UV-induced DNA repair was studied in peripheral blood lymphocytes from patients with multiple actinic keratoses (AK) requiring surgical therapy and from age-matched normal control individuals. The DNA repair activity in lymphocytes from AK patients at 4 h after UV-irradiation was 50% of that in control lymphocytes, but at 21 h the extent of DNA repair synthesis was similar to that in control cells.
摘要
对需要手术治疗的多发性光化性角化病（AK）患者及年龄匹配的正常对照个体的外周血淋巴细胞中的紫外线诱导的DNA修复进行了研究。紫外线照射后4小时，AK患者淋巴细胞中的DNA修复活性为对照淋巴细胞的50%，但在21小时时，DNA修复合成程度与对照细胞相似。
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