Egelhaaf M, Benjamin P R
J Exp Biol. 1983 Jan;102:93-114. doi: 10.1242/jeb.102.1.93.
The role of endogenous cellular properties and network interactions due to electrotonic coupling were investigated in two bilateral populations of 2-7 peripheral neurones ('Peripheral Bursters') in the snail Lymnaea stagnalis. 1. These cells are endogenously capable of bursting. Their burst frequency does not depend on the level of steady membrane polarization. Short hyperpolarizing current pulses injected during the bursting cycle induce phase advance and no phase delay in subsequent cycles, the phase advance being a function of the phase of stimulus application. Phase response and inter-burst interval curves have been constructed for short hyperpolarizing current pulses. Their shape depends on the intensity and sign of tonically injected current. This property of Peripheral Bursters is one reason for the independence of period duration from membrane polarization. 2. Coordination of burst activity of Peripheral Bursters has been studied as a function of coupling strength: whereas homolateral cells are relatively strongly electrotonically coupled and always burst synchronously, thus forming a single oscillatory unit, heterolateral cells are only weakly electrotonically coupled. Accordingly, they show more variable, though coordinated, patterns of activity. Most commonly, periods with 1:1 entrainment alternate with periods with 1:2 entrainment. The duration and frequency of occurrence of either mode of entrainment are highly variable in different preparations.
在椎实螺（Lymnaea stagnalis）中，研究了两个双边群体的2 - 7个外周神经元（“外周爆发神经元”）中由于电紧张耦合引起的内源性细胞特性和网络相互作用。1. 这些细胞具有内源性爆发能力。它们的爆发频率不依赖于稳定膜极化水平。在爆发周期中注入的短超极化电流脉冲会导致后续周期的相位提前，而不会出现相位延迟，相位提前是刺激施加相位的函数。已构建了短超极化电流脉冲的相位响应曲线和爆发间隔曲线。它们的形状取决于持续注入电流的强度和符号。外周爆发神经元的这一特性是周期持续时间与膜极化无关的一个原因。2. 已经研究了外周爆发神经元爆发活动的协调性与耦合强度的关系：同侧细胞通过电紧张相对强烈地耦合，并且总是同步爆发，从而形成一个单一的振荡单元，而异侧细胞仅通过电紧张微弱地耦合。因此，它们表现出更可变但协调的活动模式。最常见的是，1:1同步周期与1:2同步周期交替出现。在不同的标本中，任何一种同步模式的持续时间和出现频率都高度可变。
