Stone H H, Wilkinson A W
J Pediatr Surg. 1983 Feb;18(1):89-90. doi: 10.1016/s0022-3468(83)80280-2.
Clinical reviews have suggested that there are different causes for the various types of anorectal atresia and stenosis. Such inferences have primarily been based upon the presence or absence of associated fistulas and other anogenital, urinary, and more remote congenital defects. Rectal stenosis and atresia of the middle and/or upper third of the rectum were produced in 27 of 38 rabbit feti subjected to partial to complete interruption of the blood supply to the rectosigmoid colon between the 24th and 26th day of gestation. Such experimental feti were located in the right tube, while a sham laparotomy was performed during the same maternal operation on 26 feti located in the left tube. An additional undisturbed 28 feti were available in both tubes to serve as controls. No other anomalies were produced in any group. These findings suggest that local ischemia, occurring late during fetal life, may well be the mechanism responsible for the creation of rectal stenosis and atresia of the middle and/or upper rectum.
临床综述表明，各种类型的肛门直肠闭锁和狭窄存在不同病因。此类推断主要基于是否存在相关瘘管以及其他肛门生殖器、泌尿系统和更远处的先天性缺陷。在妊娠第24至26天期间，对38只兔胎儿的直肠乙状结肠进行部分至完全的血供中断，其中27只胎儿出现了直肠狭窄以及直肠中上部和/或上部闭锁。这些实验胎儿位于右侧输卵管，而在同一母体手术期间，对位于左侧输卵管的26只胎儿进行了假剖腹手术。两个输卵管中另有28只未受干扰的胎儿作为对照。任何一组均未产生其他异常。这些发现表明，胎儿期晚期发生的局部缺血很可能是导致直肠中上部和/或上部狭窄及闭锁的机制。
