Franks A J
Neuropathol Appl Neurobiol. 1978 Jan-Feb;4(1):61-70. doi: 10.1111/j.1365-2990.1978.tb00529.x.
The incidence of essential hypertension has been retrospectively studied in a group of sixty-four fatal cases of ruptured berry aneurysm, and compared with a non-fatal group. Hypertension is more frequent in the fatal group, and is associated with a higher incidence of multiple aneurysms, a smaller size of aneurysm at rupture and a poorer survival after two haemorrhages when comparison is made with normotensive patients. The possible role of hypertension in the development and rupture of aneurysms is discussed, and it is concluded that it may contribute to both. Following rupture it carries a poor prognosis with a resulting over emphasis of its significance in autopsy series. Possible mechanisms for this effect include diffuse vascular disease, and an increased liability to oedema or spasm following rupture of an aneurysm.
对一组64例因破裂性浆果状动脉瘤而死亡的病例进行了原发性高血压发病率的回顾性研究，并与非致死组进行了比较。与血压正常的患者相比，致死组中高血压更为常见，且与多发动脉瘤的发生率较高、破裂时动脉瘤较小以及两次出血后的生存率较低有关。文中讨论了高血压在动脉瘤发生和破裂中的可能作用，得出的结论是它可能在两者中都起作用。破裂后其预后较差，因此在尸检系列中对其重要性的强调过多。这种影响的可能机制包括弥漫性血管疾病，以及动脉瘤破裂后发生水肿或痉挛的易感性增加。
