Reiss C K, Volenec F J, Humphrey M, Singla O, Humphrey L J
J Surg Oncol. 1983 Apr;22(4):249-53. doi: 10.1002/jso.2930220408.
Confusion remains concerning the role of the regional lymph node in the containment of cancer. Numerous investigators using a variety of assays have reported often conflicting results concerning the immunocompetency of lymphocytes residing in regional nodes. Forty-two axillary lymph nodes from ten stage I and stage II breast cancer patients were studied in lymphocyte blast assays using mitogens and breast cancer antigen (BCA). Three general response patterns to BCA were identified which were related primarily to tumor size. In the patients with the smallest primary tumor (0.5 cm), lymphocytes in the nodes reacted to a much greater extent than peripheral blood lymphocytes (PBL). In two of three patients with intermediate-size tumor (1.0 to 1.5 cm), a mixed pattern of responses was seen with both stimulation suppression occurring within the nodes of the same patient. In the four patients with the largest tumors (2.0 to 3.0 cm), 15 of 19 nodes had a lower stimulation index (SI) than the corresponding PBL. From the results of this study it appears that regional lymph nodes are dynamic immunologic structures which regress in responsiveness as tumor burden increases.
区域淋巴结在癌症控制中的作用仍存在争议。许多研究人员使用各种检测方法，报告了关于区域淋巴结中淋巴细胞免疫能力的结果，这些结果常常相互矛盾。在使用有丝分裂原和乳腺癌抗原（BCA）的淋巴细胞增殖试验中，研究了10例I期和II期乳腺癌患者的42个腋窝淋巴结。确定了对BCA的三种一般反应模式，这些模式主要与肿瘤大小有关。在原发性肿瘤最小（0.5厘米）的患者中，淋巴结中的淋巴细胞反应程度比外周血淋巴细胞（PBL）大得多。在三名中等大小肿瘤（1.0至1.5厘米）的患者中，有两名患者出现了混合反应模式，同一患者的淋巴结内既有刺激又有抑制。在四名肿瘤最大（2.0至3.0厘米）的患者中，19个淋巴结中有15个的刺激指数（SI）低于相应的PBL。从这项研究的结果来看，区域淋巴结是动态的免疫结构，随着肿瘤负荷的增加，其反应性会降低。
