Blum J J, Hines M H
J Theor Biol. 1983 Feb 7;100(3):511-23. doi: 10.1016/0022-5193(83)90443-5.
The starting and stopping transients observed in sea urchin sperm flagella in the presence of high Ca2+ are believed to begin with an influx of Ca2+ into the axoneme and to end, as indicated by resumption of normal beating, when the Ca2+ has been reduced to very low levels by an active extrusion process. If the influx and efflux processes were uniformly distributed along the length of the flagellum, it is not likely that the starting and stopping transients would occur as a well defined sequence of events that always proceeds from the proximal to the distal end. Theoretical analysis of the concentration profiles of Ca2+ expected if Ca2+ influx occurred along the length of the flagellum but efflux was restricted to the proximal end shows that the time required to reduce [Ca2+] in the distal portion of the flagellum would generally be longer than the observed recovery times. Localization of both the influx and efflux processes near the proximal end, however, yields concentration profiles consistent with observations on the duration of starting and stopping transients.
在高钙离子存在的情况下，海胆精子鞭毛中观察到的启动和停止瞬变现象被认为始于钙离子流入轴丝，并在钙离子通过主动排出过程降至极低水平时结束，此时鞭毛恢复正常摆动。如果流入和流出过程沿鞭毛长度均匀分布，启动和停止瞬变现象不太可能以明确的事件序列发生，且该序列总是从近端向远端进行。对钙离子浓度分布的理论分析表明，如果钙离子沿鞭毛长度流入，但流出仅限于近端，那么降低鞭毛远端[Ca2+]所需的时间通常会比观察到的恢复时间更长。然而，将流入和流出过程都定位在近端附近，所产生的浓度分布与关于启动和停止瞬变持续时间的观察结果一致。
