Markman M, Braine H G, Vaughan W P
Med Pediatr Oncol. 1983;11(1):37-8. doi: 10.1002/mpo.2950110108.
Thirty-five patients with acute nonlymphocytic leukemia (ANNL) entered complete remission (CR) and survived 16 weeks following induction therapy with high-dose timed sequential chemotherapy without maintenance therapy. These patients were analyzed to test the hypothesis that acute posttransfusion hepatitis (APTH) has a beneficial influence on the course of ANNL. Ten patients developed evidence of APTH while 25 did not. Median length of CR was 22 weeks for both groups while median survival was longer in patients not developing APTH (75 weeks vs 58 weeks) (P greater than 0.5). Possible explanations for the discrepancy between these results and those previously reported are discussed.
35例急性非淋巴细胞白血病（ANNL）患者在接受大剂量定时序贯化疗诱导治疗且未进行维持治疗后进入完全缓解（CR）并存活16周。对这些患者进行分析以检验急性输血后肝炎（APTH）对ANNL病程有有益影响这一假设。10例患者出现APTH证据，而25例未出现。两组的CR中位时长均为22周，而未发生APTH的患者中位生存期更长（75周对58周）（P大于0.5）。讨论了这些结果与先前报道结果之间差异的可能解释。
