毒蕈碱样和烟碱样药物对大鼠海马树突负电位的相反作用。

Opposite actions of muscarinic and nicotinic agents on hippocampal dendritic negative fields recorded in rats.

作者信息

Rovira C, Cherubini E, Ben-Ari Y

出版信息

Neuropharmacology. 1983 Feb;22(2):239-43. doi: 10.1016/0028-3908(83)90015-1.

Abstract

In rats under urethane anaesthesia, microiontophoretic application of muscarinic or nicotinic agents, in the pyramidal layer of the hippocampus, enhanced the population spike (s) evoked by fimbrial stimulation. In contrast, muscarinic and nicotinic agents had an opposite action on on the dendritic field potentials, they respectively reduced and enhanced the negative fields (field EPSP) recorded in the apical dendrites. These effects were antagonized by muscarinic and nicotinic antagonists, respectively.

摘要

在氨基甲酸乙酯麻醉的大鼠中，在海马体锥体细胞层微量离子导入毒蕈碱或烟碱剂，增强了由海马伞刺激诱发的群体峰电位。相反，毒蕈碱和烟碱剂对树突场电位有相反的作用，它们分别降低和增强了在顶端树突中记录到的负性场（场兴奋性突触后电位）。这些效应分别被毒蕈碱和烟碱拮抗剂所拮抗。