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[洋地黄在老年医学中的应用:对窦性心律的心脏是否有效?]

[Use of digitalis in geriatrics: is it effective on the heart in sinus rhythm?].

作者信息

Almici C, Gasparotti A, De Giuli M, Vitali E, Almici C A

出版信息

Minerva Med. 1983 Mar 31;74(13):741-5.

PMID:6835563
Abstract

The therapeutic activity of digitalis in cardiac failure is linked to its positive inotropic effect on the myocardium and its ability to control cardiac activity in atrial fibrillation. Chronic stimulation with digoxin in aged subjects with sinus rhythm, however, is of debatable utility Reference is made to a series of 35 subjects (mean age 76.5 yr) in sinus rhythm, 30 of whom had been taking digoxin for over 3 yr. Clinical and instrumental parameters were assessed and heart function was classified according to the NYHA arrangement. Subjects were randomly placed in two groups matched for sex, age and cardiac condition. The first group received digoxin, the second a placebo. No significant differences between the two groups were noted over a 3-month period. In keeping with the recent literature, it is felt that digitalis is not necessary for the dynamic cardiac control of aged subjects in sinus rhythm. In addition, it is suggested that hydrosaline retention in such subjects can be controlled by restriction of salt intake, rest and diuretics.

摘要

洋地黄在心力衰竭中的治疗作用与其对心肌的正性肌力作用以及控制房颤时心脏活动的能力有关。然而,在窦性心律的老年受试者中,地高辛的长期刺激作用尚存在争议。研究涉及35名窦性心律受试者(平均年龄76.5岁),其中30人服用地高辛超过3年。评估了临床和仪器参数,并根据纽约心脏协会(NYHA)分级对心功能进行分类。受试者按性别、年龄和心脏状况随机分为两组。第一组接受地高辛治疗,第二组接受安慰剂治疗。在3个月的观察期内,两组之间未发现显著差异。与最近的文献一致,认为洋地黄对于窦性心律老年受试者的心脏动态控制并非必要。此外,建议通过限制盐摄入、休息和使用利尿剂来控制此类受试者的水盐潴留。

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