Calandra P, Lattanzi M
Minerva Med. 1978 May 9;69(23):1551-9.
Warty dyskeratoma (WD) may be observed in both whites and negros. It is usually small single isolated brown nodule with a prevalent localization of the head of aged males. During the last 4 1/2 years 20 cases were recognized at the Perugia Dermatological Clinic, representing 3.8% of 522 biopsied clinically similar skin tumors. The ratio of WD with keratoacanthoma was 1.3 and with squamous-cell carcinoma 1:5. In 4 cases a lesion clinically similar to squamous-cell carcinoma but with histological picture of WD was localized of the lower prolabium. The excision was the treatment of choice. On the basis of our findings and from a survey of the literature a clinico-pathological picture of the disease is described. Three points are emphasized: 1. WD is frequently localized on the head; when localized on the lower prolabium squamous-cell carcinoma mast be considered in differential diagnosis; 2. no clinical feature is peculiar of the disease; 3. surgical excision is essential for a correct diagnosis when histological examinations are performed on orthogonal and medial sections.
疣状角化不良瘤(WD)在白种人和黑人中均有发现。它通常是单个孤立的小褐色结节,好发于老年男性的头部。在过去4年半的时间里,佩鲁贾皮肤科诊所共确诊了20例,占522例临床症状相似的皮肤肿瘤活检病例的3.8%。WD与角化棘皮瘤的比例为1.3,与鳞状细胞癌的比例为1:5。有4例病变临床症状与鳞状细胞癌相似,但组织学表现为WD,位于下唇前部。手术切除是首选的治疗方法。基于我们的研究结果并通过文献调查,对该疾病的临床病理特征进行了描述。强调三点:1. WD常发生于头部;当发生在下唇前部时,鉴别诊断中必须考虑鳞状细胞癌;2. 该疾病没有独特的临床特征;3. 当对正交和正中切片进行组织学检查时,手术切除对于正确诊断至关重要。