Foscale M, Giacone A, Cardellino G, Garbagni R
Minerva Med. 1978 May 9;69(23):1579-84.
The arterio-alveolar CO(2) gradient was examined in 20 patients with various ventilation diseases. It increased or became negative in obstruction. The tendency to increase was attributable to distribution disturbances, particularly the marked increase in the "dead space" effect. The same picture, though to a lesser degree, owing to a smaller dead space increase, was even more frequent in restriction cases. The appearance of a gradient in healthy subjects is referable to uneven air and blood distribution in the alveoli under physiological conditions. The physiopathological significance of negative gradients is discussed in the light of the results and the findings of other workers.
对20例患有各种通气疾病的患者进行了动脉-肺泡二氧化碳梯度检查。在阻塞性疾病中该梯度升高或变为负值。升高的趋势归因于分布紊乱，尤其是“死腔”效应的显著增加。在限制性疾病中也出现同样的情况，尽管程度较轻，因为死腔增加较小，但更为常见。健康受试者中出现梯度是由于生理条件下肺泡内空气和血液分布不均。根据本研究结果以及其他研究者的发现，对负梯度的生理病理学意义进行了讨论。
