Stevens M C, Hayes R J, Serjeant G R
Pediatrics. 1983 Apr;71(4):610-4.
Body shape, defined by detailed anthropometric measurement, was compared in 64 children with homozygous sickle cell (SS) disease, and in 123 children with a normal hemoglobin (AA) genotype, aged 4 to 6 years. Children with homozygous sickle cell disease showed an average reduction in weight, height, sitting height, limb length, interacromial and intercristal diameters, and skinfold thickness. They showed increased anteroposterior chest diameters with an increased anteroposterior-lateral chest diameter ratio. This report establishes that the effect of homozygous sickle cell disease on growth patterns in childhood is apparent before the age of 6 years. The relationship to changes in body shape, seen during adolescence and in affected adults, and their possible determinants, are discussed.
通过详细的人体测量学方法对64名患有纯合子镰状细胞（SS）病的儿童和123名血红蛋白基因型正常（AA）、年龄在4至6岁的儿童的体型进行了比较。患有纯合子镰状细胞病的儿童平均体重、身高、坐高、肢体长度、肩峰间径和髂嵴间径以及皮褶厚度均有所降低。他们的胸廓前后径增加，胸廓前后径与侧径之比增大。本报告证实，纯合子镰状细胞病对儿童生长模式的影响在6岁之前就很明显。文中还讨论了与青春期及患病成年人中出现的体型变化的关系及其可能的决定因素。
