Gubetta L, Costa A
Minerva Med. 1978 Jul 14;69(34):2313-20.
Local factors with a possible influence on the frequency and histological type of thyroid cancer are examined in the light of cases observed at the Mauriziano Hospital in the last 10 years. The overall number of cases has been increasing and papilliferous forms have been more common than follicular forms. Iodine deficiency and thyrotropin hyper-stimulation encourage onset and account for the higher frequency of thyroid cancer in endemic areas, where, however, follicular forms are more common. Ironising radiation is a direct cause, particularly of papilliferous forms arising after exposure during youth.
根据过去10年在毛里齐亚诺医院观察到的病例，对可能影响甲状腺癌发病率和组织学类型的局部因素进行了研究。病例总数一直在增加，乳头状癌比滤泡状癌更为常见。碘缺乏和促甲状腺激素过度刺激会促使甲状腺癌发病，并解释了地方性甲状腺肿流行地区甲状腺癌发病率较高的原因，不过在这些地区，滤泡状癌更为常见。电离辐射是直接病因，尤其是在年轻时受辐射后引发的乳头状癌。
