Hutchins C J
Obstet Gynecol. 1978 Jul;52(1):46-9.
The estriol/creatinine ratio was determined in a first morning urine sample in 1808 pregnancies in the 32nd week of gestation. The ratio obtained correlated closely with birthweight and showed a linear increase with percentile birthweight group. There was a 25-fold increase in perinatal mortality in those pregnancies with a ratio below the tenth percentile; all pregnancies ending in stillbirths with birthweight below the tenth percentile gave such a ratio. The single estrogen/creatinine ratio allowed the early detection of a group of pregnancies at high risk of intrauterine growth retardation or major total abnormality without inconvenience for the patient.
在妊娠第32周时，对1808例孕妇的首次晨尿样本进行了雌三醇/肌酐比值测定。所获得的比值与出生体重密切相关，并随出生体重百分位数组呈线性增加。比值低于第十百分位数的孕妇围产期死亡率增加了25倍；所有出生体重低于第十百分位数的死产妊娠均呈现出这样的比值。单一的雌激素/肌酐比值能够早期检测出一组有宫内生长迟缓或严重整体异常高风险的妊娠，且对患者没有不便之处。
