Hagen M D, White R D
South Med J. 1983 Apr;76(4):503. doi: 10.1097/00007611-198304000-00025.
Two patients had severe thrombocytopenia while taking trimethoprim-sulfamethoxazole. The mechanism is uncertain, but probably is related to drug interference with folate metabolism. Recovery can usually be expected upon withdrawal of the medication and institution of folic acid therapy.
两名患者在服用复方新诺明时出现严重血小板减少症。其机制尚不清楚,但可能与药物干扰叶酸代谢有关。停药并开始叶酸治疗后通常有望康复。