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Qa-1区域与H-2K抗原之间的交叉反应性。

Crossreactivity between Qa-1 region and H-2K antigens.

作者信息

Figueroa F, Zaleska-Rutcznyska Z, Kusnierczyk P, Klein J

出版信息

Transplantation. 1983 Apr;35(4):391-3. doi: 10.1097/00007890-198304000-00025.

DOI:10.1097/00007890-198304000-00025
PMID:6836711
Abstract

Antiserum (A.TL X A.SW)F1 anti-A.TH is specific for the products of the Qa-1a region. It reacts only weakly or, under certain circumstances, not at all with the immunizing cells, but it reacts strongly with 100% of H-2f and H-2p lymphocytes. The molecules that are the target of this strong heteroclitic reactivity are controlled by a gene in the K region, most likely the K locus itself. The results are interpreted in terms of crossreactivity of Qa-1-specific antibodies with Class I major histocompatibility complex molecules. This crossreactivity underscores the relatedness of Qa and Class I loci and strengthens the argument that Qa loci are members of the Class I family.

摘要

抗血清(A.TL×A.SW)F1抗A.TH对Qa-1a区域的产物具有特异性。它与免疫细胞反应微弱,或在某些情况下根本不反应,但与100%的H-2f和H-2p淋巴细胞强烈反应。这种强烈的异种反应性所针对的分子由K区域的一个基因控制,很可能就是K基因座本身。这些结果根据Qa-1特异性抗体与I类主要组织相容性复合体分子的交叉反应性来解释。这种交叉反应性强调了Qa和I类基因座的相关性,并强化了Qa基因座是I类家族成员的观点。

相似文献

1
Crossreactivity between Qa-1 region and H-2K antigens.Qa-1区域与H-2K抗原之间的交叉反应性。
Transplantation. 1983 Apr;35(4):391-3. doi: 10.1097/00007890-198304000-00025.
2
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引用本文的文献

1
Cytotoxic T lymphocytes of the rat are predominantly restricted by RT1.A and not RT1.C-determined major histocompatibility class I antigens.大鼠的细胞毒性T淋巴细胞主要受RT1.A而非RT1.C决定的主要组织相容性I类抗原的限制。
Immunogenetics. 1984;20(1):1-12. doi: 10.1007/BF00373442.
2
Serologic cross-reactivity between Class I MHC molecules and an H-2-linked differentiation antigen as detected by monoclonal antibodies.通过单克隆抗体检测到的I类主要组织相容性复合体分子与H-2连锁分化抗原之间的血清学交叉反应性。
J Exp Med. 1984 Jan 1;159(1):21-40. doi: 10.1084/jem.159.1.21.
3
A new determinant, Qa-m208, detected on T lymphocytes and transfected L cells by a Kb-specific monoclonal antibody.
一种新的决定簇Qa-m208,通过一种Kb特异性单克隆抗体在T淋巴细胞和转染的L细胞上被检测到。
Immunogenetics. 1984;19(6):461-74. doi: 10.1007/BF00403437.
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H-2 class I antigen expression on mouse teratocarcinoma cell lines.小鼠畸胎瘤细胞系上的H-2 I类抗原表达
Immunogenetics. 1985;22(6):543-52. doi: 10.1007/BF00430302.
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H-2-specific antibodies induced by injection of syngeneic leukemia cells.通过注射同基因白血病细胞诱导产生的H-2特异性抗体。
Immunogenetics. 1987;25(4):215-21. doi: 10.1007/BF00404690.
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