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[大鼠骨骼肌线粒体适应寒冷的氧化代谢]

[Oxidative metabolism of rat skeletal muscle mitochondria in adaptation to cold].

作者信息

Belousova G P

出版信息

Tsitologiia. 1983 Jan;25(1):72-6.

PMID:6836742
Abstract

In control and cold-adapted rats the oxygen consumption was measured polarographically in isolated mitochondria of gastrocnemic and soleus muscles before denervation and 60 min afterwards. Muscle denervation decreased the direct oxidation intensity in both the groups of rats. Unlike, the intensity of phosphorylation in cold-adapted animals increased following the denervation in the soleus muscle, and decreased in the gastrocnemic muscle, whereas no changes were evident in the control rats. It is concluded that the adaptation to cold may augment the dependence of oxidative metabolism in muscle mitochondria on the central nervous control.

摘要

在对照大鼠和冷适应大鼠中,在去神经支配前及去神经支配60分钟后,用极谱法测量腓肠肌和比目鱼肌分离线粒体中的氧耗量。肌肉去神经支配降低了两组大鼠的直接氧化强度。不同的是,冷适应动物比目鱼肌去神经支配后磷酸化强度增加,腓肠肌磷酸化强度降低,而对照大鼠未出现明显变化。得出的结论是,冷适应可能增强肌肉线粒体氧化代谢对中枢神经控制的依赖性。

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