1,1-二氯乙烯对小鼠细胞色素P-450依赖的单加氧酶的肺选择性损伤及细胞损伤

Lung-selective impairment of cytochrome P-450-dependent monooxygenases and cellular injury by 1,1-dichloroethylene in mice.

作者信息

Krijgsheld K R, Lowe M C, Mimnaugh E G, Trush M A, Ginsburg E, Gram T E

出版信息

Biochem Biophys Res Commun. 1983 Jan 27;110(2):675-81. doi: 10.1016/0006-291x(83)91202-0.

Abstract

The acute toxic effects of 1,1-dichloroethylene (DCE; 125 mg/kg, i.p.) on mouse lung, liver and kidney were investigated 24 hr after its administration. DCE caused a reduction of cytochrome P-450 levels and related monooxygenases in lung microsomes with no corresponding changes in liver and kidney. Examination of the lung tissue by light microscopy revealed necrosis restricted to the Clara cells. In contrast, liver and kidney were relatively unaffected by DCE treatment, as indicated by lack of changes in microsomal monooxygenase activities and morphology.

摘要

研究了腹腔注射1,1-二氯乙烯（DCE；125毫克/千克）24小时后对小鼠肺、肝和肾的急性毒性作用。DCE导致肺微粒体中细胞色素P-450水平及相关单加氧酶减少，而肝和肾中无相应变化。光镜检查肺组织显示坏死仅限于克拉拉细胞。相比之下，如微粒体单加氧酶活性和形态无变化所示，肝和肾受DCE处理的影响相对较小。