兔血小板对3H-血小板活化因子乙酰醚的转化与聚集无关：一种新代谢产物的证据。

Conversion of 3H-PAF acether by rabbit platelets is independent from aggregation: evidences for a novel metabolite.

作者信息

Touqui L, Jacquemin C, Vargaftig B B

出版信息

Biochem Biophys Res Commun. 1983 Feb 10;110(3):890-3. doi: 10.1016/0006-291x(83)91045-8.

Abstract

3H-PAF-acether (Alkyl-[1', 2'-3H]- 2-acetyl-sn-glyceryl-3-phosphorylcholine) was time-dependently transformed by plasma-free rabbit platelets into an unknown product, "PX", which was distinct from lyso-PAF-acether. This effect was specific for platelets since plasma only converted 3H-PAF-acether into lyso-3H-PAF-acether and platelets were not effective in metabolizing lyso-3H-PAF-acether. Platelet aggregation did not interfere with the formation of "PX". The latter is a novel platelet metabolite of PAF-acether with as yet unknown biological properties.

摘要

3H-血小板活化因子乙醚（烷基-[1', 2'-3H]-2-乙酰基-sn-甘油-3-磷酸胆碱）在无血浆的兔血小板作用下随时间转化为一种未知产物“PX”，它与溶血血小板活化因子乙醚不同。这种作用对血小板具有特异性，因为血浆仅将3H-血小板活化因子乙醚转化为溶血-3H-血小板活化因子乙醚，而血小板对溶血-3H-血小板活化因子乙醚无代谢作用。血小板聚集并不干扰“PX”的形成。后者是血小板活化因子乙醚的一种新型血小板代谢产物，其生物学特性尚不清楚。