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关于镁离子和腺嘌呤核苷酸恢复被钙离子和磷酸盐去能的大鼠肝脏线粒体膜电位的机制

On the mechanism by which Mg2+ and adenine nucleotides restore membrane potential in rat liver mitochondria deenergized by Ca2+ and phosphate.

作者信息

Toninello A, Siliprandi D, Siliprandi N

出版信息

Biochem Biophys Res Commun. 1983 Mar 29;111(3):792-7. doi: 10.1016/0006-291x(83)91368-2.

DOI:10.1016/0006-291x(83)91368-2
PMID:6838586
Abstract

The presence of ATP or ADP in the incubation medium prevents the collapse of membrane potential induced by external Ca2+ and phosphate. The same adenine nucleotides are unable to restore collapsed membrane potential unless Mg2+ are also added. Bongkrekate is also able to prevent the effects of external Ca2+ and phosphate and when added after membrane potential has collapsed strongly potentiates the restorative action of ATP or ADP. Atractyloside has an opposite effect.

摘要

孵育培养基中ATP或ADP的存在可防止由外部Ca2+和磷酸盐诱导的膜电位崩溃。除非同时添加Mg2+，否则相同的腺嘌呤核苷酸无法恢复崩溃的膜电位。膨压素也能够防止外部Ca2+和磷酸盐的影响，并且在膜电位崩溃后添加时，能强烈增强ATP或ADP的恢复作用。苍术苷则具有相反的效果。

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