四氧嘧啶对体外线粒体的影响：内源性腺嘌呤核苷酸与Ca2+外流之间的相关性。
Alloxan effects on mitochondria in vitro: correlation between endogenous adenine nucleotides and efflux of Ca2+.
作者信息
Boquist L
出版信息
Biochem Int. 1984 Nov;9(5):637-41.
PMID:6525199
Abstract
The efflux of Ca2+ induced by alloxan in isolated mouse liver mitochondria was potentiated by atractylate, and by depletion of the organelles in adenine nucleotides, whereas bongkrekate, and added ATP or ADP, but not AMP, inhibited the alloxan effect. The data suggest that the Ca2+ releasing action of alloxan is dependent on the intramitochondrial pool of adenine nucleotides.
摘要
四氧嘧啶诱导的离体小鼠肝线粒体Ca2+外流可被苍术苷增强，也可因细胞器中腺嘌呤核苷酸的耗竭而增强，而膨润酸以及添加的ATP或ADP（但不是AMP）可抑制四氧嘧啶的作用。这些数据表明，四氧嘧啶的Ca2+释放作用依赖于线粒体内的腺嘌呤核苷酸池。
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