Kikuchi H, Tamura S, Nagase S, Tsuiki S
Biochim Biophys Acta. 1983 Apr 28;744(2):165-70. doi: 10.1016/0167-4838(83)90086-9.
In Nagase analbuminemic rats, serum triacylglycerol levels were significantly elevated. This abnormality was accompanied by decreased adipose tissue fat stores, and both were more marked in female than in male rats. Parametrial adipose tissue lipoprotein lipase activity was determined in normally fed female rats. When expressed per mg protein, the activity in analbuminemic rats was only 35% of that in control rats. The activity in analbuminemic rats, however, could be increased as in control rats by refeeding starved animals with a fat-free and carbohydrate-rich diet, and the peak values recorded were the same with the two groups. Treatment of animals with streptozotocin lowered adipose tissue lipoprotein lipase activity in both groups to similar levels. These results suggest that hypertriacylglycerolemia associated with analbuminemia may be caused, at least in part, by altered hormonal control of adipose tissue lipoprotein lipase activity.
在长谷川无白蛋白血症大鼠中，血清三酰甘油水平显著升高。这种异常伴随着脂肪组织脂肪储存减少，且在雌性大鼠中比雄性大鼠更为明显。在正常喂食的雌性大鼠中测定了子宫旁脂肪组织脂蛋白脂肪酶活性。以每毫克蛋白质计算时，无白蛋白血症大鼠的活性仅为对照大鼠的35%。然而，通过给饥饿的无白蛋白血症大鼠重新喂食无脂肪且富含碳水化合物的饮食，其活性可以像对照大鼠一样增加，两组记录的峰值相同。用链脲佐菌素处理动物可使两组的脂肪组织脂蛋白脂肪酶活性降低至相似水平。这些结果表明，与无白蛋白血症相关的高甘油三酯血症可能至少部分是由脂肪组织脂蛋白脂肪酶活性的激素控制改变所致。
