Benthe H F, Thieme R A
Biomed Mass Spectrom. 1983 Feb;10(2):65-73. doi: 10.1002/bms.1200100204.
After oral application of 14C labelled fendiline, 13 metabolites of this drug could be identified in human urine. Only traces of parent fendiline were excreted in the urine. The main pathway of metabolism is hydroxylation of phenyl groups with subsequent glucuronidation and sulphation. On the other hand, oxidative dealkylation occurs with the amino group remaining at the 3,3-diphenylpropyl moiety and p-hydroxyacetophenone being formed almost entirely from the 1-phenylethyl group.
口服14C标记的芬地林后，可在人尿中鉴定出该药物的13种代谢物。尿中仅排出痕量的母体芬地林。主要代谢途径是苯基的羟基化，随后是葡萄糖醛酸化和硫酸化。另一方面，发生氧化脱烷基化，氨基保留在3,3-二苯基丙基部分，对羟基苯乙酮几乎完全由1-苯乙基形成。
