对不同类型抗惊厥药物针对麻醉大鼠中由戊四氮诱发的致痫活性的活性评估。
The evaluation of different types of anti-convulsant drug activity against leptazol-induced epileptogenic activity in the anaesthetized rat.
作者信息
Kent A P, Webster R A
出版信息
Br J Pharmacol. 1983 Mar;78(3):553-9. doi: 10.1111/j.1476-5381.1983.tb08815.x.
1 The effects of various anticonvulsant drugs were evaluated quantitatively on the development of the epileptogenic EEG, induced by the intravenous infusion of leptazol in rats anaesthetized with urethane. 2 Leptazol alone produced five distinct phases of EEG activity developing from early wave and small spike and wave activity to larger spikes which later grouped and led to full body convulsion (FBC). 3 Drugs effective in petit mal such as clonazepam (0.1 and 0.25 mg kg-1) and ethosuximide (100 and 200 mg kg-1), significantly delayed the time to FBC by prolonging the early phases of the epileptogenic EEG and delaying the appearance of spiking. 4 Drugs effective in grand mal such as sodium valproate (60 mg kg-1) and phenytoin (5 mg kg-1) significantly prolonged the time to FBC by extending the later phases of the EEG and the development and grouping of spikes. Higher doses of these compounds were without effect. Carbamazepine and phenobarbitone produced mixed effects but were generally not markedly anticonvulsant. 5 The model is sensitive to drugs effective in both petit mal and grand mal, and appears able to differentiate usefully between them.
- 在用氨基甲酸乙酯麻醉的大鼠中，通过静脉输注戊四氮诱导产生致痫性脑电图，定量评估了各种抗惊厥药物对其发展的影响。2. 单独使用戊四氮会产生脑电图活动的五个不同阶段，从早期的波和小的棘波和慢波活动发展到更大的棘波，这些棘波随后聚集并导致全身惊厥（FBC）。3. 对失神发作有效的药物，如氯硝西泮（0.1和0.25mg/kg-1）和乙琥胺（100和200mg/kg-1），通过延长致痫性脑电图的早期阶段并延迟棘波的出现，显著延迟了出现全身惊厥的时间。4. 对大发作有效的药物，如丙戊酸钠（60mg/kg-1）和苯妥英（5mg/kg-1），通过延长脑电图的后期阶段以及棘波的发展和聚集，显著延长了出现全身惊厥的时间。这些化合物的更高剂量则没有效果。卡马西平和苯巴比妥产生混合效应，但一般没有明显的抗惊厥作用。5. 该模型对失神发作和大发作有效的药物敏感，并且似乎能够有效地区分它们。
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