Soto-Hall R, Saenz L, Tavernetti R, Cabaud H E, Cochran T P
Clin Orthop Relat Res. 1983 May(175):60-4.
In this prospective clinical study, ten patients were treated by revision of total hip arthroplasties utilizing tobramycin-impregnated bone cement. After the operation, serum, urine, and wound suction drainage concentrations of tobramycin were determined serially by radioimmunoassay. Although high local wound concentrations, 5.7 micrograms/ml, were maintained for as long as 48 hours, serum concentration never reached even normal therapeutic ranges (greater than 2.0 micrograms/ml). There were no immediate postoperative infections; all patients are pain-free and ambulate without external support two years after surgery. One patient who had had a preoperative infection was successfully treated for late manifestation of infection 24 months after revision. Based on the evidence obtained in this study, tobramycin in bone cement is currently acceptable for clinical use.
在这项前瞻性临床研究中，10例患者接受了使用含妥布霉素骨水泥翻修全髋关节置换术的治疗。术后，通过放射免疫测定法连续测定血清、尿液和伤口负压引流液中妥布霉素的浓度。尽管局部伤口浓度高达5.7微克/毫升，并维持了长达48小时，但血清浓度从未达到正常治疗范围（大于2.0微克/毫升）。术后无即刻感染发生；所有患者术后两年均无疼痛，无需外力支撑即可行走。1例术前有感染的患者在翻修术后24个月成功治疗了感染的晚期表现。基于本研究获得的证据，骨水泥中的妥布霉素目前可用于临床。
