[实验性甲状旁腺功能减退少尿的机制]
[Mechanism of oliguria in experimental hypoparathyroidism].
作者信息
Avanesova E O
出版信息
Probl Endokrinol (Mosk). 1978 Jul-Aug;24(4):78-81.
Diuresis was found to diminish considerably in dogs with removed (by enucleation or burning out) parathyroid glands chiefly on account of intensified tubular reabsorption. In the mechanism of oliguria in hypoparathyroidism a definite role is played by hypocalciemia. An acute reduction of blood calcium in intact dogs also suppressed diuresis. Dogs with hypoparathyroidism displayed a marked elevation of blood plasma antidiuretic activity and a high level of reabsorption of osmotically free water. Intravenous injection of adrenoblocker dihydroergotamine eliminated the suppression of diuresis in the parathyroprived dogs. Apparently, a definite role in the origin of oliguria belonged to substances of adrenergic nature.
研究发现，摘除（通过摘除或烧灼）甲状旁腺的狗的利尿作用显著减弱，这主要是由于肾小管重吸收增强所致。低钙血症在甲状旁腺功能减退少尿的机制中起一定作用。完整狗的血钙急性降低也会抑制利尿。甲状旁腺功能减退的狗血浆抗利尿活性显著升高，渗透自由水的重吸收水平也很高。静脉注射肾上腺素阻滞剂双氢麦角胺可消除甲状旁腺切除狗的利尿抑制作用。显然，肾上腺素性质的物质在少尿的发生中起一定作用。
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