Ivanenko T I
Probl Endokrinol (Mosk). 1978 Jul-Aug;24(4):86-91.
Experiments were conducted on castrated male rats. The effect of antiandrogen 17,17-dimethyl-18-norandrostadien-4,13-one-3 on the androgenic and myotrophic activity of testosterone and of some of its modified analogues, preparations with anabolic action, was studied. The intensity of the antihormonal effects depended not only on the antiandrogen dose used, but also on the dose of the agonist preparation. The author suggests a modification of the method used to assess the biological action of antiandrogens, consisting in a single administration of the "anabolic" preparation with a prolonged action and a 7-day administration of antiandrogen to castrated animals.
实验在去势雄性大鼠身上进行。研究了抗雄激素17,17 - 二甲基 - 18 - 去甲雄甾二烯 - 4,13 - 二酮 - 3对睾酮及其一些修饰类似物（具有同化作用的制剂）的雄激素活性和促肌营养活性的影响。抗激素作用的强度不仅取决于所用抗雄激素的剂量，还取决于激动剂制剂的剂量。作者建议修改用于评估抗雄激素生物作用的方法，即对去势动物单次给予长效“同化”制剂，并给予抗雄激素7天。
