Bhat R, Malalis L, Shukla A, Vidyasagar D
Chest. 1983 May;83(5):776-9. doi: 10.1378/chest.83.5.776.
Colloid osmotic pressure (COP) was measured serially in 81 critically ill neonates with hyaline membrane disease (HMD) during the first five days of life, and these changes were correlated with the birth weight, gestational age, serum protein level, clinical status, and outcome. Colloid osmotic pressure correlated better with the total protein level (n = 81; r = 0.54) than with birth weight (r = 0.23) and gestational age (r = 0.31; n = 81). Seventy-one of 81 neonates survived. Among the survivors, COP increased significantly by day 5, whereas changes in the total protein level were not significant during the same period. Colloid osmotic pressure decreased significantly in nine of ten nonsurvivors (mean +/- SE, 11 +/- 0.5 to 8 +/- 0.55 mm Hg), whereas the total protein level did not show a similar change. Thus, COP cannot be accurately predicted by measuring serum protein during acute illness. Serial measurement of COP was a better prognostic indicator than the total protein level in infants with HMD.
对81例患有透明膜病（HMD）的危重新生儿在出生后的头五天内连续测量其胶体渗透压（COP），并将这些变化与出生体重、胎龄、血清蛋白水平、临床状况及预后相关联。胶体渗透压与总蛋白水平（n = 81；r = 0.54）的相关性优于与出生体重（r = 0.23）和胎龄（r = 0.31；n = 81）的相关性。81例新生儿中有71例存活。在存活者中，到第5天时COP显著升高，而同期总蛋白水平变化不显著。在10例非存活者中有9例胶体渗透压显著降低（平均±标准误，从11±0.5降至8±0.55 mmHg），而总蛋白水平未显示出类似变化。因此，在急性疾病期间通过测量血清蛋白无法准确预测COP。对于患有HMD的婴儿，连续测量COP比总蛋白水平是更好的预后指标。
