胎鼠、新生鼠及母鼠肝脏中金属硫蛋白信使核糖核酸的水平。

Levels of metallothionein messenger RNA in foetal, neonatal and maternal rat liver.

作者信息

Andersen R D, Piletz J E, Birren B W, Herschman H R

出版信息

Eur J Biochem. 1983 Apr 5;131(3):497-500. doi: 10.1111/j.1432-1033.1983.tb07289.x.

DOI:10.1111/j.1432-1033.1983.tb07289.x

Abstract

We have used translation in vitro of hepatic polyadenylated RNA to characterize the levels of metallothionein mRNA in foetal, neonatal, pregnant and nulliparous rats. The translation products of foetal hepatic metallothionein mRNA increased relative to other mRNA translation products from day 18 of gestation to birth and attained a maximum, maintained throughout suckling, which is tenfold above 17-day foetal hepatic levels and fourfold above adult levels. Maternal liver metallothionein mRNA decreased fivefold between 17 days and 20 days of gestation, rose sharply immediately before birth, and was low throughout lactation.

摘要

我们利用肝聚腺苷酸化RNA的体外翻译来表征胎鼠、新生鼠、妊娠鼠和未孕鼠中金属硫蛋白mRNA的水平。从妊娠第18天到出生，胎肝金属硫蛋白mRNA的翻译产物相对于其他mRNA翻译产物有所增加，并在整个哺乳期保持最高水平，比胎龄17天的肝水平高10倍，比成年水平高4倍。母鼠肝脏金属硫蛋白mRNA在妊娠17天至20天之间下降了5倍，在出生前立即急剧上升，并且在整个哺乳期都处于低水平。