孕期前和/或孕期口服镉对雌性大鼠胎肝金属硫蛋白水平的影响。
Effect of oral cadmium administration to female rats before and/or during pregnancy on the metallothionein level in the fetal liver.
作者信息
Sowa B, Steibert E, Gralewska K, Piekarski M
出版信息
Toxicol Lett. 1982 May;11(3-4):233-6. doi: 10.1016/0378-4274(82)90155-2.
PMID:7101316
Abstract
Female Wistar rats received cadmium (Cd) in drinking water at a concentration of 100 ppm before and during pregnancy, prior to gestation only, and during gestation only. For the quantitative determination of metallothionein, the 203Hg-saturation method was used. Each of the 3 exposure treatments led to a decrease of the fatal metallothionein level, which may be due to disturbance in hepatic zinc (Zn) metabolism.
摘要
雌性Wistar大鼠在怀孕前和怀孕期间、仅在妊娠前以及仅在妊娠期饮用浓度为100 ppm的含镉（Cd）饮水。为了定量测定金属硫蛋白，采用了²⁰³Hg饱和法。三种暴露处理中的每一种都导致肝脏金属硫蛋白水平下降，这可能是由于肝脏锌（Zn）代谢紊乱所致。
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