Joyce J N, Davis R E, Van Hartesveldt C
Eur J Pharmacol. 1983 Feb 18;87(2-3):283-9. doi: 10.1016/0014-2999(83)90339-4.
Contralateral deviation induced by unilateral injection of 25 micrograms or 100 micrograms dopamine into the dorsal CPU was reversed to ipsilateral deviation by apomorphine administered systemically (1 mg/kg s.c.) before, at the same time, or after the dopamine. Contralateral deviation to a unilateral intrastriatal injection of 6.25 micrograms apomorphine was also reversed to ipsilateral deviation by systemically administered apomorphine. No significant effects on postural deviation were found when a control solution was injected unilaterally into the striatum, followed by systemic apomorphine. Contralateral deviation to the unilateral intrastriatal dopamine injection continued following a further bilateral intrastriatal injection of either dopamine or apomorphine. These results suggest that intrastriatal dopamine indirectly affects sites receptive to dopamine outside the striatum.
向背侧尾壳核单侧注射25微克或100微克多巴胺所诱导的对侧偏斜，在多巴胺注射前、同时或之后经皮下全身给予阿扑吗啡（1毫克/千克）后，转变为同侧偏斜。向单侧纹状体内注射6.25微克阿扑吗啡所引起的对侧偏斜，经全身给予阿扑吗啡后也转变为同侧偏斜。当向纹状体单侧注射对照溶液，随后全身给予阿扑吗啡时，未发现对姿势偏斜有显著影响。在进一步双侧纹状体内注射多巴胺或阿扑吗啡后，单侧纹状体内注射多巴胺所引起的对侧偏斜仍持续存在。这些结果表明，纹状体内多巴胺间接影响纹状体以外对多巴胺敏感的部位。
