Kovács J
Exp Cell Res. 1983 Mar;144(1):231-4. doi: 10.1016/0014-4827(83)90460-3.
A 0.25% fraction of cytoplasm was present in the autophagic vacuole compartment of the seminal vesicle cells of fasted and estrogen-treated mice. Autophagic vacuoles regressed rapidly after administration of 0.2 mg/g body weight cycloheximide to the animals and the decay appeared to follow first-order kinetics (average half-life 5.8 min, rate constant of regression 0.120 min-1). Our observations suggest that the drug suppressed the formation of autophagosomes. The fraction of cytoplasm removed by autophagy from the cells was estimated to be about 1.8% h under steady-state conditions.
禁食和雌激素处理的小鼠精囊细胞自噬泡区室中存在0.25%的细胞质部分。给动物注射0.2mg/g体重的环己酰亚胺后，自噬泡迅速消退，消退似乎遵循一级动力学（平均半衰期5.8分钟，消退速率常数0.120分钟-1）。我们的观察结果表明，该药物抑制了自噬体的形成。在稳态条件下，通过自噬从细胞中去除的细胞质部分估计约为1.8%/小时。
