Gabriel N N, Soliman K F
Horm Res. 1983;17(1):43-8. doi: 10.1159/000179673.
Acetylcholinesterase (AchE, EC 3.1.1.7) activity was determined in cerebral cortex, hypothalamus, adenohypophysis and adrenal gland in response to acute and chronic stress. Chronic exposure of animals to cold stress (at 4 degrees C for 7 days) resulted in significant decline of AchE activity in all tissues studied. Similar results were obtained when animals were exposed to acute immobilization and cold stress (at 4 degrees C) simultaneously. In another experiment, animals were treated with 2 mg/kg of corticosterone prior to AchE determination. Corticosterone administration resulted in a significant decline in AchE activity of the cortex, the hypothalamus and the adrenal but failed to affect the adenohypophysis AchE level. Exposing adrenalectomized animals to acute stress resulted in no significant changes in the cortex and the hypothalamus but caused a significant decline in AchE of the adenohypophysis. It was concluded from this study that corticosterone might mediate the stress effect on AchE activity.
测定了大脑皮层、下丘脑、腺垂体和肾上腺中乙酰胆碱酯酶（AchE，EC 3.1.1.7）的活性，以研究急性和慢性应激的影响。动物长期暴露于寒冷应激（4℃，持续7天）会导致所有研究组织中AchE活性显著下降。当动物同时暴露于急性制动和寒冷应激（4℃）时，也得到了类似的结果。在另一项实验中，在测定AchE之前，给动物注射2mg/kg的皮质酮。注射皮质酮导致大脑皮层、下丘脑和肾上腺中AchE活性显著下降，但对腺垂体AchE水平没有影响。将肾上腺切除的动物暴露于急性应激下，大脑皮层和下丘脑没有显著变化，但腺垂体AchE活性显著下降。该研究得出结论，皮质酮可能介导应激对AchE活性的影响。
