Renis M, Giovine A, Bertolino A
Pharmacology. 1978;17(1):1-7. doi: 10.1159/000136828.
Brain mitochondria were prepared from rat brain stem and cerebral cortex. Four substrates were used for enzyme characterization: dopamine, serotonin, noradrenaline and tryptamine. Monoamine oxidase (MAO) activities were tested on two different groups of rats treated with ethanol and tetrahydropapaveroline (THP); another group was used as control group. Data obtained show that there is almost always activation of MAO activities after acute treatment with either ethanol or THP, while after chronic treatment, the two drugs show opposite effects. In particular, the same type of MAO activity continues to be activated by ethanol, whereas it is inhibited by THP.
脑线粒体取自大鼠脑干和大脑皮层。使用四种底物进行酶特性分析：多巴胺、血清素、去甲肾上腺素和色胺。在两组分别用乙醇和四氢罂粟碱（THP）处理的大鼠上测试单胺氧化酶（MAO）活性；另一组用作对照组。获得的数据表明，急性给予乙醇或THP后，MAO活性几乎总会被激活，而慢性给药后，这两种药物显示出相反的效果。具体而言，乙醇持续激活同类型的MAO活性，而THP则抑制该活性。
