Valbonesi M, Florio G, Montani F, Mosconi L
Int J Artif Organs. 1983 Mar;6(2):87-90.
A simple method for the study of kinetic solubility curves of cryoglobulins is presented. In its first application to the study of 21 patients with cryoglobulinemia, it was possible to ascertain that clinical condition roughly correlates with decreased solubility whereas no correlation is found with per cent cryocrit. In the group of patients we studied, 6 underwent plasma exchange treatment when glomerulonephritis, acute renal insufficiency, cerebritis and polyneuropathy appeared: in these patients, following 2 to 5 apheretic sessions, solubility increased showing a sort of correlation with clinical benefits determined by treatment. The preliminarity of this study is underlined.
本文介绍了一种研究冷球蛋白动力学溶解度曲线的简单方法。首次将其应用于21例冷球蛋白血症患者的研究时，发现临床状况大致与溶解度降低相关，而与冷沉淀比容百分比无关。在我们研究的患者组中，6例患者在出现肾小球肾炎、急性肾功能不全、脑炎和多发性神经病时接受了血浆置换治疗：在这些患者中，经过2至5次血液分离治疗后，溶解度增加，显示出与治疗所带来的临床益处存在某种相关性。强调了本研究的初步性。
