Hyperphagia and obesity following ventromedial hypothalamic lesions in rats with subdiaphragmatic vagotomy.

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作者信息

King B M, Carpenter R G, Stamoutsos B A, Frohman L A, Grossman S P

出版信息

Physiol Behav. 1978 May;20(5):643-51. doi: 10.1016/0031-9384(78)90258-5.

DOI:10.1016/0031-9384(78)90258-5

PMID:684099

Abstract

摘要

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Hyperphagia and obesity following ventromedial hypothalamic lesions in rats with subdiaphragmatic vagotomy.

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Hypothalamic hyperphagia prevented by prior subdiaphragmatic vagotomy: insulin hyperphagia is unaffected.

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Hypothalamic hypoactivity prevented but not reversed by subdiaphragmatic vagotomy.下丘脑活动减退可被膈下迷走神经切断术预防但不能逆转。

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Vagotomy blocks hypothalamic hyperphagia in rats on a chow diet and sucrose solution, but not on a palatable mixed diet.迷走神经切断术可阻断食用普通饲料和蔗糖溶液的大鼠的下丘脑性摄食亢进，但对美味混合饲料喂养的大鼠无效。

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Sham feeding in rats after ventromedial hypothalamic lesions and vagotomy.

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Hyperphagia and obesity in the guinea pig produced by hypothalamic knife cuts.

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Ingestive behavior in adult rats with dorsomedial hypothalamic lesions.成年大鼠下丘脑背内侧核损伤后的摄食行为

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Vagal mediation of hypothalamic obesity but not of supermarket dietary obesity.迷走神经对下丘脑性肥胖有调节作用，但对超市饮食性肥胖无调节作用。

Am J Physiol. 1980 May;238(5):R447-53. doi: 10.1152/ajpregu.1980.238.5.R447.

Food-motivated performance in rats with ventromedial hypothalamic lesions: effects of body weight, deprivation, and preoperative training.

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Prolonged exposure to food odors suppresses feeding via an olfactory bulb-to-hypothalamus circuit.长时间暴露于食物气味中会通过嗅球到下丘脑的神经回路抑制进食。

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Subdiaphragmatic Vagotomy With Pyloroplasty Ameliorates the Obesity Caused by Genetic Deletion of the Melanocortin 4 Receptor in the Mouse.膈下迷走神经切断术联合幽门成形术可改善因黑素皮质素4受体基因缺失导致的小鼠肥胖。

Front Neurosci. 2018 Mar 1;12:104. doi: 10.3389/fnins.2018.00104. eCollection 2018.

The role of hyperinsulinema and the vagus nerve in hypothalamic hyperphagia reexamined.重新审视高胰岛素血症和迷走神经在下丘脑性多食症中的作用。

Diabetologia. 1981 Mar;20(Suppl 1):402-410. doi: 10.1007/BF00254509.

Insulin acting as a modulator of feeding through the hypothalamus.胰岛素通过下丘脑调节摄食。

Diabetologia. 1981 Mar;20(Suppl 1):290-298. doi: 10.1007/BF00254495.

Effects of subdiaphragmatic vagotomy on energy balance and thermogenesis in the rat.膈下迷走神经切断术对大鼠能量平衡和产热的影响。

J Physiol. 1985 May;362:1-12. doi: 10.1113/jphysiol.1985.sp015658.

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